Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694108 | 0.84 | PTGS1 (0.55) | PTGS1PTGS2SLC2A1MAPT | |
| SCHEMBL694447 | 0.84 | MAPT (0.41) | PTGS1PTGS2KDM4EMEN1MAPT | |
| SCHEMBL693706 | 0.82 | MAPT (0.50) | PTGS1PTGS2SNCASLC2A1KDM4E | |
| SCHEMBL5116259 | 0.75 | PTGS2 (0.76) | PTGS1PTGS2SNCASLC2A1 | |
| SCHEMBL694132 | 0.75 | TNKS2 (0.41) | KDM4EMEN1MAPTKMT2A | |
| SCHEMBL441514 | 0.71 | SLC2A1 (0.43) | PTGS1PTGS2SNCAPDE3BPDE3A | |
| SCHEMBL6620032 | 0.70 | DAO (0.43) | TAAR1DAO | |
| SCHEMBL4053484 | 0.69 | MAPT (0.54) | KDM4EMEN1MAPTKMT2A | |
| SCHEMBL6615346 | 0.68 | HSP90AA1 (0.41) | DAO | |
| SCHEMBL437834 | 0.68 | SLC2A1 (0.45) | PTGS1PTGS2SNCAPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |