Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 3/20 | 0.55 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.55 |
| ▸ | MAOB | P27338 | 7/20 | 0.53 |
| ▸ | TLR3 | O15455 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601951 | 0.85 | MAOB (0.53) | KCNE1KCNQ1MAOBCA2CA5A | |
| SCHEMBL8481853 | 0.81 | KCNE1 (0.54) | KCNE1KCNQ1MAOBCA2CA5A | |
| SCHEMBL6603299 | 0.79 | KCNE1 (0.54) | KCNE1KCNQ1MAOBCA2CA5A | |
| SCHEMBL8481846 | 0.79 | KCNE1 (0.54) | KCNE1KCNQ1MAOBCA2CA5A | |
| SCHEMBL8481843 | 0.79 | KCNE1 (0.52) | KCNE1KCNQ1MAOBCA2CA5A | |
| SCHEMBL6603457 | 0.78 | KCNE1 (0.66) | KCNE1KCNQ1MAOBMAOAALDH1A1 | |
| SCHEMBL6602406 | 0.78 | KCNE1 (0.52) | KCNE1KCNQ1MAOBCA2CA5A | |
| SCHEMBL6601126 | 0.78 | KCNE1 (0.68) | KCNE1KCNQ1MAOBCA2MAOA | |
| SCHEMBL6934369 | 0.78 | KCNE1 (0.61) | KCNE1KCNQ1MAOBCA2CA5A | |
| SCHEMBL4011395 | 0.77 | TLR3 (0.42) | KCNE1KCNQ1TLR3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913396-B1 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6008245-A | TREATMENT OF PROPHYLAXIS AND CARDIOVASCULAR DISORDERS, IN PARTICULAR ARRHYTHMIAS, FOR THE TREATMENT OF ULCERS OF THE GASTROINTESTINAL DISORDERS, DIARRHEAL DISEASES | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 1999-12-28 | — | — | US | disclosed |
| EP-0913396-A2 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-06 | — | — | EP | disclosed |