Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375903 | 0.83 | CA1 (0.55) | MAPTCA1ALDH1A1KDM4EHPGD | |
| SCHEMBL11794387 | 0.82 | CA1 (0.54) | MAPTCA1ALDH1A1KDM4EHPGD | |
| SCHEMBL6939049 | 0.80 | ALDH1A1 (0.45) | MAPTCA1ALDH1A1SLC6A3SLC6A4 | |
| SCHEMBL6676417 | 0.80 | CA1 (0.43) | MAPTCA1ALDH1A1SLC6A3SLC6A4 | |
| SCHEMBL6940261 | 0.80 | SLC6A3 (0.44) | MAPTCA1ALDH1A1SLC6A3SLC6A2 | |
| SCHEMBL13254544 | 0.80 | MAPT (0.92) | MAPTCA1ALDH1A1SLC6A3SLC6A2 | |
| SCHEMBL30031079 | 0.80 | MAPT (0.92) | MAPTCA1ALDH1A1SLC6A3SLC6A2 | |
| SCHEMBL3485391 | 0.80 | MAPT (0.92) | MAPTCA1ALDH1A1SLC6A3SLC6A2 | |
| SCHEMBL14292322 | 0.80 | MAPT (0.92) | MAPTCA1ALDH1A1SLC6A3SLC6A2 | |
| SCHEMBL6676434 | 0.80 | ALDH1A1 (0.49) | CA1ALDH1A1SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |