Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159940 | 0.89 | OPRM1 (0.40) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL5163165 | 0.88 | OPRM1 (0.44) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL6936946 | 0.87 | OPRM1 (0.43) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL6938750 | 0.87 | OPRM1 (0.40) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL5160480 | 0.85 | SLC6A4 (0.58) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL6938734 | 0.84 | SLC6A3 (0.46) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5161148 | 0.83 | SLC6A4 (0.38) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL6936278 | 0.83 | SLC6A3 (0.44) | OPRM1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6939119 | 0.83 | SLC6A4 (0.45) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| SCHEMBL6941375 | 0.82 | OPRM1 (0.41) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |