Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934471 | 0.88 | OPRM1 (0.44) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6936761 | 0.88 | SLC6A2 (0.52) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL5159940 | 0.86 | OPRM1 (0.40) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6937411 | 0.85 | OPRM1 (0.56) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL5163165 | 0.85 | OPRM1 (0.44) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6937445 | 0.85 | MAPT (0.41) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6936946 | 0.84 | OPRM1 (0.43) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL4663546 | 0.83 | OPRD1 (0.44) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6938734 | 0.83 | SLC6A3 (0.46) | SLC6A4SLC6A2 | |
| SCHEMBL6939493 | 0.83 | SLC6A2 (0.41) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1406857-B1 | SUBSTITUTED 1-ARYL-BUT-3-ENYLAMINE AND 1-ARYL-BUT-2-ENYLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2007-02-21 | — | — | EP | disclosed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| JP-2000327642-A | 3-AMINO-3-ARYLPROPAN-1-OL DERIVATIVE, ITS PRODUCTION AND USE | GRUENENTHAL GMBH | 2000-11-28 | — | — | JP | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |