Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 19/20 | 0.50 |
| ▸ | METAP1 | P53582 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932837 | 0.80 | METAP2 (0.46) | METAP2METAP1 | |
| SCHEMBL7074810 | 0.76 | METAP2 (0.45) | METAP2METAP1 | |
| SCHEMBL6939438 | 0.74 | METAP2 (0.55) | METAP2METAP1KDM4E | |
| SCHEMBL6942550 | 0.73 | METAP2 (0.48) | METAP2METAP1 | |
| SCHEMBL6937329 | 0.72 | METAP2 (0.47) | METAP2METAP1 | |
| SCHEMBL4002804 | 0.72 | KDM4E (0.45) | KDM4EMPOCYP1A2CYP3A4ADORA3 | |
| SCHEMBL6477367 | 0.71 | METAP2 (0.67) | METAP2METAP1 | |
| SCHEMBL6476415 | 0.71 | METAP2 (0.64) | METAP2METAP1KDM4E | |
| SCHEMBL7171815 | 0.70 | KDM4E (0.57) | KDM4EMPOCYP1A2CYP3A4ADORA3 | |
| SCHEMBL6938548 | 0.70 | METAP2 (0.50) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | disclosed |