Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | NPY4R | P50391 | 9/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.35 |
| ▸ | NPY1R | P25929 | 5/20 | 0.35 |
| ▸ | NPY2R | P49146 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416968 | 0.91 | NPY4R (0.36) | NPY4RNPY5RNPY1RNPY2RALOX15 | |
| SCHEMBL7099770 | 0.79 | ITGB3 (0.47) | ITGB3ITGA2B | |
| SCHEMBL6938012 | 0.77 | NPY4R (0.32) | EPHX2NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL7103319 | 0.77 | ITGB3 (0.46) | ITGB3ITGA2B | |
| SCHEMBL6937805 | 0.75 | NPY4R (0.34) | EPHX2NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL7348479 | 0.72 | EPHX2 (0.41) | EPHX2NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL7350352 | 0.72 | EPHX2 (0.41) | EPHX2NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL7349462 | 0.72 | EPHX2 (0.41) | EPHX2NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL7347873 | 0.72 | EPHX2 (0.41) | EPHX2NPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL7355782 | 0.72 | EPHX2 (0.41) | EPHX2NPY4RNPY5RNPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097127-B1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2003-03-12 | — | — | EP | claimed |
| US-6326403-B1 | CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-12-04 | — | — | US | claimed |
| EP-1097127-B1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6326403-B1 | CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-12-04 | — | — | US | disclosed |
| EP-1097127-A1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000003973-A1 | DIACYLHYDRAZINE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |