Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.62 |
| ▸ | RARG | P13631 | 10/20 | 0.62 |
| ▸ | RARA | P10276 | 9/20 | 0.62 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.62 |
| ▸ | BLVRB | P30043 | 1/20 | 0.62 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RXRA | P19793 | 9/20 | 0.46 |
| ▸ | RXRB | P28702 | 8/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935697 | 0.85 | RARB (0.64) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL32685293 | 0.85 | RARB (0.68) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL1615912 | 0.82 | RARB (0.65) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6447266 | 0.81 | RARB (0.59) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6345181 | 0.80 | RARB (0.58) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL1614827 | 0.80 | CYP26A1 (0.58) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8461601 | 0.78 | CYP26A1 (0.82) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL1615110 | 0.77 | RARA (0.80) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL19560600 | 0.77 | RARA (0.80) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL36207 | 0.77 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280757-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001083438-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |