Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | ANPEP | P15144 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | LAP3 | P28838 | 1/20 | 0.33 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947400 | 1.00 | ADAM17 (0.46) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL6947403 | 0.89 | ADAM17 (0.45) | ADAM17APPMMP2MMP9ANPEP | |
| SCHEMBL6983937 | 0.89 | ADAM17 (0.42) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL7955132 | 0.88 | ADAM17 (0.44) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL7835552 | 0.88 | ADAM17 (0.44) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL6942243 | 0.88 | ADAM17 (0.40) | ADAM17MMP2MMP9ALDH1A1GAA | |
| SCHEMBL6943375 | 0.87 | ADAM17 (0.53) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL6939910 | 0.86 | ADAM17 (0.57) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL6947352 | 0.86 | ADAM17 (0.51) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL6947109 | 0.86 | ADAM17 (0.57) | ADAM17TGFBR1P2RX3APPMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |