Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937845 | 0.88 | ADAM17 (0.46) | ADAM17MMP1MMP9GAAALDH1A1 | |
| SCHEMBL6947400 | 0.88 | ADAM17 (0.46) | ADAM17MMP1MMP9GAAALDH1A1 | |
| SCHEMBL6940024 | 0.84 | ADAM17 (0.48) | ADAM17MMP1MMP13MMP9SMN1; SMN2 | |
| SCHEMBL6947186 | 0.83 | ADAM17 (0.52) | ADAM17MMP1MMP13MMP9HTT | |
| SCHEMBL6983937 | 0.83 | ADAM17 (0.42) | ADAM17MMP9ALDH1A1MMP2GRIK1 | |
| SCHEMBL7955132 | 0.83 | ADAM17 (0.44) | ADAM17MMP9ALDH1A1MMP2GRIK1 | |
| SCHEMBL7835552 | 0.83 | ADAM17 (0.44) | ADAM17MMP9ALDH1A1MMP2GRIK1 | |
| SCHEMBL6941116 | 0.83 | ADAM17 (0.56) | ADAM17MMP1MMP13MMP9HTT | |
| SCHEMBL6943375 | 0.81 | ADAM17 (0.53) | ADAM17MMP1MMP13MMP9GAA | |
| SCHEMBL6946530 | 0.80 | ADAM17 (0.40) | ADAM17MMP1MMP13MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |