Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955132 | 1.00 | ADAM17 (0.44) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6983937 | 0.90 | ADAM17 (0.42) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6947400 | 0.88 | ADAM17 (0.46) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6937845 | 0.88 | ADAM17 (0.46) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6946530 | 0.88 | ADAM17 (0.40) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6946529 | 0.88 | ADAM17 (0.40) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6945370 | 0.88 | ADAM17 (0.49) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6945376 | 0.88 | ADAM17 (0.49) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6940169 | 0.87 | ADAM17 (0.45) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6943375 | 0.87 | ADAM17 (0.53) | ADAM17TGFBR1MMP2MMP9ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |