Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tomoxiprole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tomoxiprole SCHEMBL525023 | 0.91 | MAPK9 (0.50) | MAPK9MAPK14CNR2CNR1CASR | |
| SCHEMBL11078304 | 0.80 | MAPK9 (0.47) | MAPK9MAPK14CNR2CNR1KMT2A | |
| SCHEMBL11076902 | 0.79 | MAPK9 (0.46) | MAPK9MAPK14CNR2CNR1CASR | |
| SCHEMBL11085482 | 0.79 | MAPK9 (0.47) | MAPK9MAPK14CNR2CNR1KMT2A | |
| SCHEMBL11075543 | 0.79 | TLR7 (0.43) | CASRKMT2AMEN1KDM4EPOLB | |
| SCHEMBL11073129 | 0.75 | PARP1 (0.55) | MAPK9MAPK14CNR2CNR1KMT2A | |
| SCHEMBL11078399 | 0.73 | MAPK9 (0.48) | MAPK9MAPK14CNR2CNR1KMT2A | |
| SCHEMBL11024220 | 0.72 | MAPK9 (0.50) | MAPK9MAPK14CNR2CNR1KMT2A | |
| SCHEMBL11079618 | 0.72 | GRIK2 (0.52) | MAPK9MAPK14CNR2KMT2AMEN1 | |
| SCHEMBL11078944 | 0.72 | MAPK9 (0.50) | MAPK9MAPK14CNR2CNR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573252-B1 | Therapy and prevention of bony disorders; improved gastrointestinal tolerability | NICOX, S.A. (FR) | 2003-06-03 | — | — | US | disclosed |
| EP-1100805-B1 | MEDICINE NITRATE SALTS | NICOX SA (FR) | 2002-12-11 | — | — | EP | disclosed |
| EP-1100805-A1 | MEDICINE NITRATE SALTS | NICOX S.A. (FR) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006585-A1 | MEDICINE NITRATE SALTS | NICOX S.A. (FR) | 2000-02-10 | — | — | WO | disclosed |