Sugi Predict

Sugi Predict / Compounds / SCHEMBL6937951

SCHEMBL6937951

SCHEMBL6937951

CCSCC[C@@H](N)C(O)C(=O)N(N)C(=O)c1cccc(SC(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ METAP2 P50579 19/20 0.46
▸ METAP1 P53582 11/20 0.46
▸ LMNA P02545 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6564913 0.83 METAP2 (0.53) METAP2METAP1
SCHEMBL6477894 0.80 METAP2 (0.71) METAP2METAP1
SCHEMBL7308710 0.79 METAP2 (0.64) METAP2METAP1
SCHEMBL6939440 0.77 METAP2 (0.56) METAP2METAP1
SCHEMBL6937626 0.76 METAP2 (0.47) METAP2METAP1LMNA
SCHEMBL6937335 0.75 METAP2 (0.46) METAP2METAP1
SCHEMBL6940131 0.74 METAP2 (0.50) METAP2METAP1
SCHEMBL7075750 0.74 METAP2 (0.49) METAP2METAP1
SCHEMBL6942554 0.74 METAP2 (0.45) METAP2METAP1
SCHEMBL6563437 0.74 METAP2 (0.44) METAP2METAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1272456-A1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS Abbott Laboratories (US) 2003-01-08 — — EP claimed
WO-2001079157-A1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 2001-10-25 — — WO claimed