Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 4/20 | 0.33 |
| ▸ | IDH2 | P48735 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | ESRRA | P11474 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945332 | 0.86 | HPGD (0.34) | ALDH1A1KDM4EMAPT | |
| SCHEMBL6939946 | 0.84 | NPC1 (0.36) | ALDH1A1ESRRAPTPN1MAPT | |
| SCHEMBL6946921 | 0.84 | — | — | |
| SCHEMBL6943242 | 0.84 | L3MBTL1 (0.32) | ALDH1A1KDM4EMAPT | |
| SCHEMBL6946104 | 0.84 | TGFBR1 (0.31) | — | |
| SCHEMBL6940042 | 0.83 | SMN1; SMN2 (0.33) | ALDH1A1MAPT | |
| SCHEMBL8099189 | 0.82 | — | — | |
| SCHEMBL6941637 | 0.81 | NPC1 (0.34) | ALDH1A1ESRRAPTPN1KDM4EMAPT | |
| SCHEMBL6942383 | 0.80 | TGFBR1 (0.32) | — | |
| SCHEMBL6946850 | 0.78 | TGFBR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |