Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938178 | 1.00 | TK1 (0.40) | TK1PRMT5KMT2AMEN1MAPT | |
| SCHEMBL6940163 | 0.80 | ADRB2 (0.41) | TK1KMT2AMEN1MAPTGAA | |
| SCHEMBL6940159 | 0.80 | ADRB2 (0.41) | TK1KMT2AMEN1MAPTGAA | |
| SCHEMBL6939460 | 0.79 | HTR2A (0.46) | KMT2AMEN1LMNAHPGDKDM4E | |
| SCHEMBL6939466 | 0.79 | HTR2A (0.46) | KMT2AMEN1LMNAHPGDKDM4E | |
| SCHEMBL6933500 | 0.79 | CDK4 (0.45) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL6933502 | 0.79 | CDK4 (0.45) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL6939120 | 0.77 | MEN1 (0.38) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL6942595 | 0.76 | MEN1 (0.38) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL6941805 | 0.74 | TP53 (0.46) | PRMT5KMT2AMEN1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596738-B1 | Inhibiting activity to adenosine deaminase (hereinafter described as ADA) An adenosine deaminase inhibiting agent comprising a compound of the formula (I): | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |