Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11704768 | 1.00 | TYR (0.59) | TYRAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL29954993 | 1.00 | TYR (0.59) | TYRAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL59197 | 0.84 | PTGS2 (0.74) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL11471204 | 0.82 | AKR1C3 (0.59) | TYRAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11434457 | 0.82 | PTGS2 (0.55) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL1140292 | 0.82 | TYR (0.57) | TYRAKR1C3AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL11434458 | 0.82 | PTGS2 (0.55) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL6775188 | 0.82 | PTGS2 (0.64) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL9420395 | 0.82 | PTGS2 (0.55) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL1346361 | 0.82 | PTGS2 (0.55) | AKR1C3AKR1C2PTGS2PTGS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116046948-A | Related substance analysis method of compound preparation ibuprofen renin tablet | 南京工业大学 | 2023-05-02 | — | — | CN | claimed |
| JP-4368353-A | — | — | None | — | — | JP | disclosed |
| CN-116626188-A | Method for detecting impurity morpholine in pebiprofen | 湖南九典宏阳制药有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-116046948-A | Related substance analysis method of compound preparation ibuprofen renin tablet | 南京工业大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-113149826-A | Preparation process of pelubiprofen | 台州市源众药业有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-107353195-B | Preparation method of loxoprofen sodium ring-opening impurity | 迪嘉药业集团有限公司 | 2020-10-13 | — | — | CN | disclosed |
| CN-106316837-A | Preparation method for substituted phenylacetic acid derivatives | 浙江九洲药业股份有限公司 | 2017-01-11 | — | — | CN | disclosed |
| EP-2733534-B1 | COMPOSITION FOR FORMING FINE PATTERN AND METHOD FOR FORMING FINED PATTERN USING SAME | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| US-9394275-B2 | Diamide compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity | THERAVANCE RESPIRATORY COMPANY, LLC (US) | 2016-07-19 | — | — | US | disclosed |
| US-9298094-B2 | Composition for forming fine pattern and method for forming fined pattern using same | MERCK PATENT GMBH (DE) | 2016-03-29 | — | — | US | disclosed |
| EP-0689845-A2 | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis | AMERICAN CYANAMID COMPANY (US) | 1996-01-03 | — | — | EP | disclosed |
| JP-H04368353-A | PRODUCTION OF 2-(P-FORMYLPHENYL)PROPIONIC ACID | SANKYO CO LTD | 1992-12-21 | — | — | JP | disclosed |
| EP-0169688-B1 | PROCESS FOR PREPARING ANTI-INFLAMMATORY CYCLOALKYLIDENEMETHYLPHENYLACETIC ACID DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1988-09-28 | — | — | EP | disclosed |
| US-4673761-A | Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives | SANKYO COMPANY, LIMITED (JP) | 1987-06-16 | — | — | US | disclosed |
| EP-0169688-A1 | Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives | SANKYO COMPANY LIMITED (JP) | 1986-01-29 | — | — | EP | disclosed |
| US-4407823-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-10-04 | — | — | US | disclosed |
| EP-0007319-A1 | Indan-1-carboxylic acid derivatives,process for their preparation and pharmaceutical preparations containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-02-06 | — | — | EP | disclosed |
| US-4064132-A | ANTIINFLAMMATORY AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-12-20 | — | — | US | disclosed |
| US-4060528-A | ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-11-29 | — | — | US | disclosed |
| US-4035376-A | ESTERS, AMIDES, HYDROXAMIC ACIDS, ANTIINFLAMMATORY | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |