Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.64 |
| ▸ | PPARA | Q07869 | 10/20 | 0.64 |
| ▸ | PPARD | Q03181 | 5/20 | 0.64 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | FOS | P01100 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935714 | 0.86 | PPARG (0.61) | PPARGPPARAPPARDLTB4RLMNA | |
| SCHEMBL6936861 | 0.81 | PPARA (0.59) | PPARGPPARAPPARDLTB4RLMNA | |
| SCHEMBL6934325 | 0.80 | PPARG (0.59) | PPARGPPARAPPARDLTB4RFOS | |
| SCHEMBL6938370 | 0.80 | PPARG (0.58) | PPARGPPARAPPARDLTB4RFOS | |
| SCHEMBL18480010 | 0.79 | POLB (0.55) | PPARGPPARAPPARDLTB4RLMNA | |
| SCHEMBL13236857 | 0.77 | KMT2A (0.68) | LMNAMAPK1L3MBTL1KMT2A | |
| SCHEMBL1196100 | 0.77 | PLA2G4B (0.58) | LMNAKMT2A | |
| SCHEMBL24648565 | 0.76 | PPARG (0.56) | PPARGPPARAPPARDLTB4RELANE | |
| SCHEMBL30020306 | 0.76 | PPARG (0.56) | PPARGPPARAPPARDLTB4RELANE | |
| SCHEMBL18917586 | 0.76 | LMNA (0.69) | PPARALMNAMAPK1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | claimed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |