Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938774 | 1.00 | MAOB (0.47) | MAOBLTA4HTSHRSMN1; SMN2MEN1 | |
| SCHEMBL5612567 | 0.88 | ACHE (0.34) | MAOBSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5207997 | 0.86 | LTA4H (0.52) | LTA4HTSHRSMN1; SMN2LMNA | |
| SCHEMBL8347164 | 0.81 | CA4 (0.43) | LTA4HTSHRKMT2AGAALMNA | |
| SCHEMBL5898125 | 0.81 | CA4 (0.43) | LTA4HTSHRKMT2AGAALMNA | |
| SCHEMBL6202477 | 0.81 | CA4 (0.43) | LTA4HTSHRKMT2AGAALMNA | |
| Ammonia Solution, Strong SCHEMBL30411567 | 0.79 | CA4 (0.42) | LTA4HTSHRKMT2AGAALMNA | |
| SCHEMBL1173711 | 0.78 | LTA4H (0.75) | MAOBLTA4HTSHRSMN1; SMN2MEN1 | |
| SCHEMBL4025817 | 0.78 | LTA4H (0.75) | MAOBLTA4HTSHRSMN1; SMN2MEN1 | |
| SCHEMBL30211827 | 0.78 | LTA4H (0.75) | MAOBLTA4HTSHRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |