Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945549 | 0.99 | TDP1 (0.41) | TDP1SMN1; SMN2LMNAALDH1A1TBXAS1 | |
| Hydrochloric Acid SCHEMBL6575511 | 0.89 | TDP1 (0.40) | TDP1SMN1; SMN2ALDH1A1TBXAS1MAOA | |
| SCHEMBL6573733 | 0.88 | TDP1 (0.40) | TDP1SMN1; SMN2ALDH1A1TBXAS1MAOA | |
| Hydrochloric Acid SCHEMBL6945005 | 0.85 | LMNA (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL6944203 | 0.83 | LMNA (0.41) | SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL6944489 | 0.82 | SMN1; SMN2 (0.41) | TDP1SMN1; SMN2LMNAALDH1A1TBXAS1 | |
| SCHEMBL6946419 | 0.81 | SMN1; SMN2 (0.41) | TDP1SMN1; SMN2LMNAALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL6945134 | 0.81 | HTR7 (0.40) | SMN1; SMN2LMNAALDH1A1TSHRMEN1 | |
| Hydrochloric Acid SCHEMBL6942135 | 0.80 | LMNA (0.42) | SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6938793 | 0.80 | HTR7 (0.41) | SMN1; SMN2LMNAALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |