SCHEMBL6939271

SCHEMBL6939271

CCOC(=O)c1ccc(-c2ccc(O)c(F)c2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 4/20 0.59
CA1 P00915 4/20 0.59
CA2 P00918 4/20 0.59
CA7 P43166 4/20 0.59
CA9 Q16790 4/20 0.59
CA14 Q9ULX7 4/20 0.59
LMNA P02545 2/20 0.59
KDM4E B2RXH2 1/20 0.59
HSD17B10 Q99714 1/20 0.59
ESR1 P03372 1/20 0.56
ESR2 Q92731 1/20 0.56
HSD17B2 P37059 3/20 0.54
CYP3A4 P08684 2/20 0.50
HSD17B1 P14061 2/20 0.50
CYP1A2 P05177 1/20 0.50
MAOA P21397 1/20 0.50
PDK2 Q15119 1/20 0.49
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
MAPT P10636 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL184993 0.87 CA12 (0.72) CA12CA1CA2CA7CA9
SCHEMBL28659596 0.84 CA12 (0.63) CA12CA1CA2CA7CA9
SCHEMBL9626744 0.84 MAPT (0.58) CA12CA1CA2CA7CA9
SCHEMBL10586688 0.84 MAPT (0.58) CA12CA1CA2CA7CA9
SCHEMBL30016425 0.82 CA1 (0.59) CA12CA1CA2CA7CA9
SCHEMBL345875 0.82 CA1 (0.59) CA12CA1CA2CA7CA9
SCHEMBL31347271 0.82 CA1 (0.59) CA12CA1CA2CA7CA9
SCHEMBL1965326 0.82 CA1 (0.73) CA12CA1CA2CA7CA9
SCHEMBL16351874 0.82 CA1 (0.73) CA12CA1CA2CA7CA9
SCHEMBL4849260 0.81 MAPT (0.56) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0962445-B1 Acetylene compound, liquid crystal composition and liquid crystal element MITSUI CHEMICALS INC (JP) 2003-02-26 EP disclosed
US-6217793-B1 Acetylene compound, liquid crystal composition and liquid crystal element MITSUI CHEMICALS, INC. (JP) 2001-04-17 US disclosed
EP-0962445-A1 Acetylene compound, liquid crystal composition and liquid crystal element Mitsui Chemicals, Inc. (JP) 1999-12-08 EP disclosed