Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 11/20 | 0.38 |
| ▸ | MMP3 | P08254 | 8/20 | 0.38 |
| ▸ | MMP7 | P09237 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 7/20 | 0.37 |
| ▸ | MMP9 | P14780 | 6/20 | 0.37 |
| ▸ | MMP8 | P22894 | 4/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940033 | 0.93 | ADAM17 (0.49) | ADAM17MMP2MMP9MMP8MMP13 | |
| SCHEMBL6940945 | 0.88 | ADAM17 (0.75) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6939936 | 0.86 | ADAM17 (0.56) | ADAM17MMP2MMP7MMP1MMP9 | |
| SCHEMBL6944720 | 0.84 | ADAM17 (0.54) | ADAM17MMP2MMP3MMP1MMP9 | |
| SCHEMBL6943824 | 0.84 | ADAM17 (0.55) | ADAM17MMP2MMP3MMP1MMP9 | |
| SCHEMBL6939403 | 0.84 | ADAM17 (0.55) | ADAM17MMP2MMP3MMP1MMP9 | |
| SCHEMBL6945656 | 0.83 | ADAM17 (0.71) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6943011 | 0.81 | ADAM17 (0.65) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6940910 | 0.81 | ADAM17 (0.67) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6944738 | 0.80 | ADAM17 (0.64) | ADAM17MMP2MMP3MMP7MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |