Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 15/20 | 0.40 |
| ▸ | MMP1 | P03956 | 14/20 | 0.40 |
| ▸ | MMP3 | P08254 | 14/20 | 0.40 |
| ▸ | MMP8 | P22894 | 14/20 | 0.40 |
| ▸ | MMP13 | P45452 | 14/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939403 | 0.98 | ADAM17 (0.55) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6942478 | 0.85 | ADAM17 (0.41) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6943846 | 0.84 | ADAM17 (0.40) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6940945 | 0.84 | ADAM17 (0.75) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6939612 | 0.84 | ADAM17 (0.58) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6939936 | 0.83 | ADAM17 (0.56) | ADAM17MMP2MMP1MMP13MMP9 | |
| SCHEMBL6944720 | 0.81 | ADAM17 (0.54) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6945656 | 0.80 | ADAM17 (0.71) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6939485 | 0.79 | ADAM17 (0.75) | ADAM17MMP2MMP1MMP3MMP8 | |
| SCHEMBL6946042 | 0.78 | ADAM17 (0.74) | ADAM17MMP2MMP1MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |