Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936768 | 0.89 | SLC6A9 (0.39) | SLC6A4SLC6A2OPRM1SLC22A1CHRM2 | |
| SCHEMBL6942328 | 0.89 | SLC6A4 (0.47) | SLC6A4SLC6A2OPRM1SLC22A1CHRM2 | |
| SCHEMBL6939054 | 0.88 | SLC6A4 (0.42) | SLC6A4SLC6A2OPRD1OPRK1SLC6A3 | |
| Hydrochloric Acid SCHEMBL7741185 | 0.88 | OPRL1 (0.39) | SLC6A4SLC6A2OPRM1SLC22A1CHRM2 | |
| SCHEMBL6937424 | 0.87 | TRPA1 (0.44) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL5846320 | 0.87 | SLC6A4 (0.36) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5847568 | 0.86 | SLC6A4 (0.36) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6934477 | 0.82 | SLC6A4 (0.52) | SLC6A4SLC6A2OPRM1SLC22A1CHRM2 | |
| SCHEMBL5845144 | 0.82 | TRPA1 (0.35) | SLC6A4SLC6A2OPRM1SLC22A1CHRM2 | |
| Hydrochloric Acid SCHEMBL5846909 | 0.81 | TRPA1 (0.34) | SLC6A4SLC6A2OPRM1SLC22A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |