Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 10/20 | 0.44 |
| ▸ | AQP1 | P29972 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936768 | 0.91 | SLC6A9 (0.39) | TRPA1SLC6A9SLC6A2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL7741185 | 0.90 | OPRL1 (0.39) | TRPA1SLC6A9SLC6A2SLC6A4OPRM1 | |
| SCHEMBL5846320 | 0.89 | SLC6A4 (0.36) | TRPA1SLC6A9SLC6A2SLC6A4OPRM1 | |
| SCHEMBL5845144 | 0.88 | TRPA1 (0.35) | TRPA1SLC6A2SLC6A4OPRM1MEN1 | |
| SCHEMBL6937427 | 0.88 | TRPA1 (0.38) | TRPA1SLC6A2SLC6A4OPRM1MEN1 | |
| Hydrochloric Acid SCHEMBL5847568 | 0.88 | SLC6A4 (0.36) | TRPA1SLC6A9SLC6A2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL5846909 | 0.87 | TRPA1 (0.34) | TRPA1SLC6A2SLC6A4OPRM1MEN1 | |
| SCHEMBL6939736 | 0.87 | SLC6A4 (0.40) | SLC6A2SLC6A4OPRM1MEN1OPRD1 | |
| SCHEMBL6937028 | 0.86 | TRPA1 (0.38) | TRPA1SLC6A2SLC6A4OPRM1MEN1 | |
| SCHEMBL6939845 | 0.86 | TRPA1 (0.38) | TRPA1SLC6A2SLC6A4OPRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |