Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937410 | 0.90 | HSD11B1 (0.37) | CCR5SLC6A4SLC6A2KMT2A | |
| SCHEMBL5162314 | 0.89 | CCR5 (0.38) | CCR5SLC6A4SLC6A2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5846847 | 0.88 | CCR5 (0.37) | CCR5SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL5846308 | 0.85 | CCR5 (0.38) | CCR5SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL5845800 | 0.84 | SLC6A4 (0.42) | CCR5SLC6A4SLC6A2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5847559 | 0.84 | CCR5 (0.37) | CCR5SLC6A4SLC6A2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5846073 | 0.83 | SLC6A2 (0.42) | CCR5SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL6936962 | 0.83 | SLC6A4 (0.40) | CCR5SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6942930 | 0.82 | SLC6A2 (0.45) | CCR5SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6939842 | 0.81 | MEN1 (0.37) | CCR5SLC6A4SLC6A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |