Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7738593 | 0.99 | SLC6A2 (0.44) | SLC6A2SLC6A4CCR5SLC6A3OPRM1 | |
| SCHEMBL5845800 | 0.94 | SLC6A4 (0.42) | SLC6A2SLC6A4CCR5SLC6A3OPRM1 | |
| Hydrochloric Acid SCHEMBL5846073 | 0.93 | SLC6A2 (0.42) | SLC6A2SLC6A4CCR5SLC6A3OPRM1 | |
| SCHEMBL6939083 | 0.89 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3OPRM1KDR | |
| SCHEMBL6936762 | 0.89 | SLC6A9 (0.39) | SLC6A4SLC6A3OPRM1KDROPRD1 | |
| SCHEMBL5846308 | 0.88 | CCR5 (0.38) | SLC6A2SLC6A4CCR5SLC6A3OPRM1 | |
| SCHEMBL6936962 | 0.88 | SLC6A4 (0.40) | SLC6A2SLC6A4CCR5SLC6A3OPRL1 | |
| Hydrochloric Acid SCHEMBL7741182 | 0.88 | OPRL1 (0.39) | SLC6A4SLC6A3OPRM1KDROPRD1 | |
| SCHEMBL6934468 | 0.87 | SLC6A3 (0.42) | SLC6A2SLC6A4CCR5SLC6A3 | |
| Hydrochloric Acid SCHEMBL5847559 | 0.87 | CCR5 (0.37) | SLC6A2SLC6A4CCR5SLC6A3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |