Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | CASP2 | P42575 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17536233 | 0.88 | ALDH1A1 (0.67) | ALDH1A1HTTSMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL30021051 | 0.84 | TDP1 (0.61) | P2RX7LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3757797 | 0.84 | KMT2A (0.73) | LMNAALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL31554508 | 0.84 | P2RX7 (0.59) | P2RX7LMNAALDH1A1HTTKMT2A | |
| SCHEMBL7930528 | 0.84 | P2RX7 (0.59) | P2RX7LMNAALDH1A1HTTKMT2A | |
| SCHEMBL22897585 | 0.83 | ALDH1A1 (0.51) | P2RX7ALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL9095943 | 0.83 | POLB (0.64) | P2RX7LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6689214 | 0.82 | MAPT (0.57) | P2RX7LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9095157 | 0.82 | ALDH1A1 (0.61) | P2RX7LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3704664 | 0.82 | GAA (0.61) | P2RX7LMNAALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555541-B1 | P2X7 receptor antagonists for treatment of inflammatory respiratory system disorders such as asthma; for example, 2-(3,4-Difluorophenylamino)-N-(2-methyl-5-piperazin-1-yl-methyl-phenyl) -acetamide, trihydrochloride | ASTRAZENECA UK LIMITED (GB) | 2003-04-29 | — | — | US | disclosed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| EP-1185522-A1 | SUBSTITUTED PHENYL COMPOUNDS WITH IMMUNOSUPPRESSING ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2002-03-13 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |
| WO-2000071529-A1 | SUBSTITUTED PHENYL COMPOUNDS WITH IMMUNOSUPPRESSING ACTIVITY AND PHARMACEUTICAL COMPOSITIONS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |
| EP-1036058-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029660-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |