Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679404 | 0.89 | SLC6A2 (0.42) | SLC6A2SLC6A4SIGMAR1NISCHPDE7A | |
| SCHEMBL6940299 | 0.89 | SLC6A2 (0.44) | SLC6A2SLC6A4SIGMAR1NISCHOPRL1 | |
| SCHEMBL5162314 | 0.89 | CCR5 (0.38) | SLC6A2SLC6A4ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5846847 | 0.88 | CCR5 (0.37) | SLC6A2SLC6A4ALDH1A1MEN1KMT2A | |
| SCHEMBL6676667 | 0.84 | SLC6A2 (0.40) | SLC6A2SLC6A4SIGMAR1NISCHPDE7A | |
| SCHEMBL6681024 | 0.83 | SLC6A4 (0.39) | SLC6A2SLC6A4MEN1KMT2ASIGMAR1 | |
| SCHEMBL6941158 | 0.83 | SLC6A2 (0.39) | SLC6A2SLC6A4NISCHOPRL1OPRM1 | |
| SCHEMBL6936746 | 0.83 | ALDH1A1 (0.38) | SLC6A2SLC6A4ALDH1A1MEN1KMT2A | |
| SCHEMBL6680122 | 0.82 | SLC6A2 (0.42) | SLC6A2SLC6A4SIGMAR1NISCHOPRL1 | |
| SCHEMBL6676963 | 0.82 | SLC6A2 (0.38) | SLC6A2SLC6A4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |