Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.41 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950160 | 0.89 | SMN1; SMN2 (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6946973 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6949353 | 0.80 | TUBB4A (0.40) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6943470 | 0.78 | ERCC5 (0.50) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6946187 | 0.78 | PTPN1 (0.47) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| Dimethylamine SCHEMBL6943493 | 0.78 | LMNA (0.42) | KDM4EALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL6951260 | 0.78 | TUBB4A (0.47) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6948187 | 0.77 | ERCC5 (0.40) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6945647 | 0.77 | SMN1; SMN2 (0.47) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6951318 | 0.76 | ERCC5 (0.39) | KDM4EALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |