Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951319 | 0.90 | ERCC5 (0.39) | LMNASMN1; SMN2ERCC5FEN1KDM4E | |
| SCHEMBL6946187 | 0.88 | PTPN1 (0.47) | LMNASMN1; SMN2MAPTRAB9AKDM4E | |
| SCHEMBL6946973 | 0.87 | KDM4E (0.46) | LMNASMN1; SMN2MAPTRAB9AL3MBTL1 | |
| SCHEMBL6951986 | 0.87 | KDM4E (0.37) | SMN1; SMN2MAPTRAB9AL3MBTL1ERCC5 | |
| SCHEMBL6943490 | 0.86 | ALDH1A1 (0.45) | SMN1; SMN2KDM4EKMT2AALDH1A1 | |
| SCHEMBL6948187 | 0.82 | ERCC5 (0.40) | LMNASMN1; SMN2MAPTL3MBTL1ERCC5 | |
| SCHEMBL6951318 | 0.81 | ERCC5 (0.39) | LMNASMN1; SMN2MAPTL3MBTL1ERCC5 | |
| Dimethylamine SCHEMBL6947095 | 0.79 | ERCC5 (0.50) | SMN1; SMN2MAPTERCC5FEN1NPSR1 | |
| SCHEMBL6951983 | 0.79 | KDM4E (0.37) | LMNASMN1; SMN2MAPTRAB9AL3MBTL1 | |
| SCHEMBL6949353 | 0.78 | TUBB4A (0.40) | LMNAMAPTRAB9AL3MBTL1ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |