Ethylene Glycol

Ethylene Glycol

SCHEMBL6941246

C=Cc1cc(N)ccc1N.OCCO

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.34
RECQL P46063 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
MEN1 O00255 1/20 0.34
USP2 O75604 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
PKM P14618 1/20 0.34
APEX1 P27695 1/20 0.34
BLM P54132 1/20 0.34
KMT2A Q03164 1/20 0.34
MCL1 Q07820 1/20 0.34
CASP1 P29466 2/20 0.33
ALDH1A1 P00352 2/20 0.33
CYP3A4 P08684 2/20 0.33
ALOX15 P16050 2/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RAD52 P43351 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene Glycol SCHEMBL6946032 0.98 THRB (0.33) THRBRECQLTDP1MEN1USP2
SCHEMBL3480852 0.89 CASP1 (0.37) THRBRECQLTDP1MEN1USP2
SCHEMBL5253253 0.75 CASP1 (0.40) THRBRECQLTDP1MEN1USP2
SCHEMBL25941241 0.73 PTPN11 (0.39) RECQLMEN1POLBMAPTKMT2A
SCHEMBL7691805 0.73 NQO2 (0.33) RECQLTDP1KMT2AALDH1A1HPGD
SCHEMBL3677559 0.72 CA14 (0.41) THRBRECQLTDP1CASP1ALDH1A1
SCHEMBL3679569 0.72 CA1 (0.46) THRBRECQLTDP1MEN1POLB
SCHEMBL6310983 0.72 RECQL (0.37) THRBRECQLTDP1MEN1USP2
SCHEMBL6310979 0.72 RECQL (0.37) THRBRECQLTDP1MEN1USP2
SCHEMBL3680895 0.72 CASP1 (0.42) RECQLTDP1MEN1POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0999203-B1 Novel developer in oxidative hair dyeing CLAIROL INC (US) 2003-02-26 EP claimed
US-6228130-B1 1-(2,5-DIAMINOPHENYL)ETHYLENE GLYCOL; WATER SOLUBLE; P-PHENYLENEDIAMINE REPLACEMENT BRISTOL-MYERS SQUIBB COMPANY 2001-05-08 US claimed
EP-0999203-A1 Novel developer in oxidative hair dyeing Bristol-Myers Squibb Company (US) 2000-05-10 EP claimed
EP-0999203-B1 Novel developer in oxidative hair dyeing CLAIROL INC (US) 2003-02-26 EP disclosed
EP-1006104-B1 P-aminophenol substitute and its use in oxidation dye formulations CLAIROL INC (US) 2002-09-25 EP disclosed
US-6228130-B1 1-(2,5-DIAMINOPHENYL)ETHYLENE GLYCOL; WATER SOLUBLE; P-PHENYLENEDIAMINE REPLACEMENT BRISTOL-MYERS SQUIBB COMPANY 2001-05-08 US disclosed
US-6228130-B1 1-(2,5-DIAMINOPHENYL)ETHYLENE GLYCOL; WATER SOLUBLE; P-PHENYLENEDIAMINE REPLACEMENT BRISTOL-MYERS SQUIBB COMPANY 2001-05-08 US disclosed
EP-1006104-A1 P-aminophenol substitute and its use in oxidation dye formulations Bristol-Myers Squibb Company (US) 2000-06-07 EP disclosed
JP-2000143592-A NEW PRINCIPAL INTERMEDIATE FOR OXIDATIVE HAIR DYE BRISTOL MYERS SQUIBB CO 2000-05-23 JP disclosed
EP-0999203-A1 Novel developer in oxidative hair dyeing Bristol-Myers Squibb Company (US) 2000-05-10 EP disclosed
EP-0999203-A1 Novel developer in oxidative hair dyeing Bristol-Myers Squibb Company (US) 2000-05-10 EP disclosed
US-5980584-A NONTOXIC; REPLACEMENT FOR P-AMINOPHENOL IN OXIDATIVE HAIR DYE SYSTEMS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US disclosed