Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939401 | 0.87 | P2RX7 (0.71) | P2RX7ABCB11GPR55MAPK1NPSR1 | |
| SCHEMBL6939404 | 0.85 | P2RX7 (0.72) | P2RX7ABCB11GPR55MAPK1NPSR1 | |
| SCHEMBL7071927 | 0.84 | P2RX7 (0.61) | P2RX7ABCB11GPR55NPSR1 | |
| SCHEMBL6860227 | 0.81 | P2RX7 (1.00) | P2RX7ABCB11MAPK1 | |
| SCHEMBL6939826 | 0.81 | P2RX7 (0.68) | P2RX7ABCB11GPR55 | |
| SCHEMBL6941167 | 0.81 | ALDH1A1 (0.61) | P2RX7ABCB11NPSR1 | |
| SCHEMBL6943104 | 0.78 | P2RX7 (0.76) | P2RX7ABCB11MAPK1NPSR1 | |
| SCHEMBL6941223 | 0.77 | P2RX7 (0.70) | P2RX7ABCB11GPR55 | |
| SCHEMBL6939407 | 0.76 | P2RX7 (0.72) | P2RX7ABCB11 | |
| SCHEMBL7956634 | 0.76 | P2RX7 (0.72) | P2RX7ABCB11GPR55MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |