Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694387 | 0.83 | CYP19A1 (0.38) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL3304536 | 0.82 | NPC1 (0.51) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL22044815 | 0.81 | NPC1 (0.61) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL11659928 | 0.77 | KDM4E (0.63) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL11729688 | 0.76 | CYP19A1 (0.69) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL5053299 | 0.75 | NPC1 (0.87) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL27325010 | 0.75 | NPC1 (0.53) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL11659391 | 0.75 | KDM4E (0.63) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL4582223 | 0.74 | KDR (0.54) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL29804862 | 0.74 | RAB9A (0.71) | NPC1RAB9AKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |