Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 5/20 | 0.35 |
| ▸ | MMP3 | P08254 | 8/20 | 0.34 |
| ▸ | MMP2 | P08253 | 8/20 | 0.34 |
| ▸ | MMP1 | P03956 | 7/20 | 0.34 |
| ▸ | MMP8 | P22894 | 6/20 | 0.34 |
| ▸ | MMP13 | P45452 | 6/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942694 | 0.91 | ADAM17 (0.51) | ADAM17BCHEBMP1MMP3MMP2 | |
| SCHEMBL6939562 | 0.87 | ADAM17 (0.40) | ADAM17BCHEBMP1MMP3MMP2 | |
| SCHEMBL6940034 | 0.84 | ADAM17 (0.52) | ADAM17MMP3MMP2MMP1MMP8 | |
| SCHEMBL6940361 | 0.83 | ADAM17 (0.37) | ADAM17BCHEBMP1MMP3MMP2 | |
| SCHEMBL6947526 | 0.78 | ADAM17 (0.47) | ADAM17MMP3MMP2MMP1MMP8 | |
| SCHEMBL6945603 | 0.77 | ADAM17 (0.38) | ADAM17BMP1MMP3MMP2MMP1 | |
| SCHEMBL6942207 | 0.74 | ADAM17 (0.51) | ADAM17MMP3MMP2MMP1MMP8 | |
| SCHEMBL6947013 | 0.73 | MMP1 (0.52) | ADAM17MMP3MMP2MMP1MMP8 | |
| SCHEMBL6945863 | 0.72 | ADAM17 (0.55) | ADAM17MMP3MMP2MMP1MMP8 | |
| SCHEMBL6980963 | 0.71 | MMP1 (0.36) | ADAM17BCHEBMP1MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |