Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.52 |
| ▸ | MMP8 | P22894 | 13/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 16/20 | 0.42 |
| ▸ | MMP13 | P45452 | 8/20 | 0.42 |
| ▸ | MMP3 | P08254 | 12/20 | 0.42 |
| ▸ | MMP9 | P14780 | 5/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 1/20 | 0.32 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947526 | 0.89 | ADAM17 (0.47) | MMP1MMP8ADAM17MMP2MMP13 | |
| SCHEMBL6944230 | 0.81 | ADAM17 (0.40) | MMP1MMP8ADAM17MMP2MMP13 | |
| SCHEMBL6947666 | 0.81 | ADAM17 (0.37) | MMP1MMP8ADAM17 | |
| SCHEMBL7928825 | 0.81 | ADAM17 (0.37) | MMP1MMP8ADAM17 | |
| SCHEMBL6940034 | 0.80 | ADAM17 (0.52) | MMP1MMP8ADAM17MMP2MMP13 | |
| SCHEMBL6942694 | 0.78 | ADAM17 (0.51) | MMP1MMP8ADAM17MMP2MMP13 | |
| SCHEMBL6945579 | 0.78 | ADAM17 (0.62) | MMP1MMP8ADAM17MMP2MMP13 | |
| SCHEMBL6942207 | 0.74 | ADAM17 (0.51) | MMP1MMP8ADAM17MMP2MMP13 | |
| SCHEMBL6945324 | 0.74 | ADAM17 (0.37) | ADAM17 | |
| SCHEMBL8098302 | 0.73 | ADAM17 (0.66) | MMP1MMP8ADAM17MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |