Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
| ▸ | ANPEP | P15144 | 2/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945788 | 0.94 | ADAM17 (0.31) | ADAM17P2RX3MGLLMMP2MMP9 | |
| SCHEMBL6946721 | 0.93 | ADAM17 (0.32) | ADAM17TGFBR1P2RX3MGLLMMP2 | |
| SCHEMBL6945554 | 0.93 | ADAM17 (0.33) | ADAM17TGFBR1P2RX3MGLLMMP2 | |
| SCHEMBL7937084 | 0.91 | ALDH1A1 (0.33) | ADAM17P2RX3MGLLMMP2MMP9 | |
| SCHEMBL6943876 | 0.91 | ADAM17 (0.31) | ADAM17P2RX3MGLLMMP2MMP9 | |
| SCHEMBL6942209 | 0.91 | ADAM17 (0.33) | ADAM17TGFBR1P2RX3MGLLMMP2 | |
| SCHEMBL8111706 | 0.91 | ADAM17 (0.33) | ADAM17TGFBR1P2RX3MGLLMMP2 | |
| SCHEMBL6943556 | 0.91 | ADAM17 (0.33) | ADAM17TGFBR1P2RX3MGLLMMP2 | |
| SCHEMBL6943358 | 0.90 | ADAM17 (0.32) | ADAM17TGFBR1P2RX3MMP2MMP9 | |
| SCHEMBL6946731 | 0.90 | ADAM17 (0.33) | ADAM17TGFBR1P2RX3MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |