Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
| ▸ | ANPEP | P15144 | 2/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | LAP3 | P28838 | 1/20 | 0.30 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.30 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.30 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943876 | 0.94 | ADAM17 (0.31) | P2RX3ADAM17MGLLMMP2MMP9 | |
| SCHEMBL6943399 | 0.93 | ALDH1A1 (0.34) | ALDH1A1GAAP2RX3KLK7ADAM17 | |
| SCHEMBL6946721 | 0.93 | ADAM17 (0.32) | P2RX3ADAM17MGLLMMP2MMP9 | |
| SCHEMBL6945554 | 0.93 | ADAM17 (0.33) | ALDH1A1P2RX3ADAM17MGLLMMP2 | |
| SCHEMBL6942260 | 0.92 | ALDH1A1 (0.32) | ALDH1A1GAAP2RX3KLK7ADAM17 | |
| SCHEMBL6945788 | 0.91 | ADAM17 (0.31) | P2RX3ADAM17MGLLMMP2MMP9 | |
| SCHEMBL6942507 | 0.91 | FKBP1A (0.32) | P2RX3ADAM17MGLLMMP2MMP9 | |
| SCHEMBL6943358 | 0.91 | ADAM17 (0.32) | ALDH1A1GAAP2RX3ADAM17MMP2 | |
| SCHEMBL6943556 | 0.91 | ADAM17 (0.33) | ALDH1A1GAAP2RX3ADAM17MGLL | |
| SCHEMBL6942209 | 0.91 | ADAM17 (0.33) | ALDH1A1GAAP2RX3ADAM17MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |