Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 5/20 | 0.42 |
| ▸ | MMP9 | P14780 | 5/20 | 0.42 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | MMP13 | P45452 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.39 |
| ▸ | PTAFR | P25105 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942708 | 0.92 | ADAM17 (0.49) | ADAM17MMP2MMP9TBXAS1PTAFR | |
| SCHEMBL6942091 | 0.87 | ADAM17 (0.46) | ADAM17MMP2MMP9MMP1MMP13 | |
| SCHEMBL6942216 | 0.87 | ADAM17 (0.43) | ADAM17MMP2MMP9TBXAS1PTAFR | |
| SCHEMBL6942387 | 0.78 | ADAM17 (0.71) | ADAM17MMP2MMP9MMP1MMP13 | |
| SCHEMBL6945579 | 0.78 | ADAM17 (0.62) | ADAM17MMP2MMP9MMP1MMP13 | |
| SCHEMBL7099919 | 0.76 | ADAM17 (0.51) | ADAM17MMP2MMP9MMP1MMP13 | |
| SCHEMBL7105151 | 0.76 | ADAM17 (0.50) | ADAM17MMP2MMP9MMP1MMP13 | |
| SCHEMBL7100619 | 0.76 | ADAM17 (0.50) | ADAM17MMP2MMP9MMP1MMP13 | |
| SCHEMBL7076170 | 0.75 | MMP1 (0.49) | ADAM17MMP2MMP9MMP1MMP13 | |
| SCHEMBL6940003 | 0.75 | ADAM17 (0.70) | ADAM17MMP2MMP9MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |