Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FCER2 | P06734 | 4/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939992 | 0.92 | ADAM17 (0.41) | MMP1MMP13ADAM17MMP8TSHR | |
| SCHEMBL6941765 | 0.87 | ADAM17 (0.52) | MMP1MMP13ADAM17MMP8FCER2 | |
| SCHEMBL6941577 | 0.83 | MMP1 (0.50) | MMP1MMP13ADAM17MMP8TSHR | |
| SCHEMBL6945858 | 0.81 | ADAM17 (0.57) | MMP1MMP13ADAM17MMP8MMP2 | |
| SCHEMBL6940214 | 0.80 | ADAM17 (0.48) | MMP1MMP13ADAM17MMP8FCER2 | |
| SCHEMBL6940945 | 0.80 | ADAM17 (0.75) | MMP1MMP13ADAM17MMP8FCER2 | |
| SCHEMBL6939522 | 0.79 | MMP1 (0.47) | MMP1MMP13MMP8TSHRFCER2 | |
| SCHEMBL6939528 | 0.79 | MMP1 (0.47) | MMP1MMP13MMP8TSHRFCER2 | |
| SCHEMBL6940260 | 0.78 | MMP2 (0.56) | MMP1MMP13ADAM17MMP8FCER2 | |
| SCHEMBL6939949 | 0.78 | ADAM17 (0.47) | MMP1MMP13ADAM17MMP8FCER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |