Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.54 |
| ▸ | RXRB | P28702 | 8/20 | 0.54 |
| ▸ | RXRG | P48443 | 6/20 | 0.54 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | RARB | P10826 | 10/20 | 0.53 |
| ▸ | RARG | P13631 | 9/20 | 0.53 |
| ▸ | RARA | P10276 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941012 | 0.88 | RXRA (0.55) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL10645869 | 0.83 | CYP26A1 (0.47) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL6941283 | 0.79 | RARB (0.67) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9051293 | 0.77 | RARB (0.66) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL31191741 | 0.77 | RARB (0.66) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9051275 | 0.77 | RARB (0.66) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9051287 | 0.77 | RARB (0.66) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL9318594 | 0.76 | RXRA (0.70) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL8839146 | 0.75 | RXRA (0.67) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL7243713 | 0.74 | RXRA (0.68) | RXRARXRBRXRGCYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280757-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001083438-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |