Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.68 |
| ▸ | RARB | P10826 | 11/20 | 0.68 |
| ▸ | RARG | P13631 | 10/20 | 0.68 |
| ▸ | RXRB | P28702 | 8/20 | 0.68 |
| ▸ | RARA | P10276 | 8/20 | 0.68 |
| ▸ | RXRG | P48443 | 6/20 | 0.68 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.57 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9318594 | 0.86 | RXRA (0.70) | RXRARARBRARGRXRBRARA | |
| SCHEMBL28518784 | 0.84 | RXRA (0.70) | RXRARARBRARGRXRBRARA | |
| SCHEMBL9195653 | 0.84 | CYP26A1 (0.48) | RXRARARBRARGRXRBRARA | |
| SCHEMBL6818089 | 0.81 | RXRA (1.00) | RXRARARBRARGRXRBRARA | |
| SCHEMBL29827631 | 0.81 | RARB (0.81) | RXRARARBRARGRXRBRARA | |
| SCHEMBL846110 | 0.81 | RARB (0.81) | RXRARARBRARGRXRBRARA | |
| SCHEMBL9208986 | 0.80 | RXRA (0.78) | RXRARARBRARGRXRBRARA | |
| Hydrochloric Acid SCHEMBL9120757 | 0.79 | RARB (0.78) | RXRARARBRARGRXRBRARA | |
| SCHEMBL8839146 | 0.79 | RXRA (0.67) | RXRARARBRARGRXRBRARA | |
| SCHEMBL10580178 | 0.78 | CYP26A1 (0.47) | RXRARARBRARGRXRBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030219832-A1 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities | KLEIN ELLIOTT S (US) | 2003-11-27 | — | — | US | claimed |
| US-20020156054-A1 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities | ALLERGAN, INC. | 2002-10-24 | — | — | US | claimed |
| EP-0853610-A2 | SYNTHESIS AND USE OF RETINOID COMPOUNDS HAVING NEGATIVE HORMONE AND/OR ANTAGONIST ACTIVITIES | Allergan (US) | 1998-07-22 | — | — | EP | claimed |
| WO-1997009297-A2 | SYNTHESIS AND USE OF RETINOID COMPOUNDS HAVING NEGATIVE HORMONE AND/OR ANTAGONIST ACTIVITIES | VISION PHARMACEUTICALS L.P. (US) | 1997-03-13 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030219832-A1 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities | RXRA, RARA, RXRG | RXRA 1/4885RARB 7/4885RARG 4/4885 |
| US-20020156054-A1 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities | RXRA, RARA, RXRG | RXRA 1/4885RARB 7/4885RARG 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.