Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948834 | 0.87 | GAA (0.33) | ALDH1A1TSHR | |
| SCHEMBL6802919 | 0.69 | GAA (0.47) | ALDH1A1TSHR | |
| SCHEMBL9026938 | 0.68 | KDM4E (0.31) | — | |
| SCHEMBL27655266 | 0.68 | ALDH1A1 (0.42) | ALDH1A1ALOX15TSHRTDP1 | |
| SCHEMBL11317425 | 0.65 | ALDH1A1 (0.39) | ALDH1A1ALOX15TSHRTDP1 | |
| SCHEMBL7760107 | 0.65 | ALDH1A1 (0.39) | ALDH1A1ALOX15TSHR | |
| SCHEMBL6954684 | 0.63 | GAA (0.54) | ALDH1A1TSHRTDP1 | |
| SCHEMBL11158001 | 0.60 | ALDH1A1 (0.43) | ALDH1A1TSHR | |
| SCHEMBL6129391 | 0.60 | ALDH1A1 (0.42) | ALDH1A1ALOX15TSHR | |
| SCHEMBL28798940 | 0.60 | ALDH1A1 (0.42) | ALDH1A1CYP3A4ALOX15TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140899-B1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY | SCHERING CORP (US) | 2003-09-10 | — | — | EP | disclosed |
| EP-1140899-A1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY | SCHERING CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6271378-B1 | Process for preparing tricyclic compounds having antihistaminic activity | SCHERING CORPORATION | 2001-08-07 | — | — | US | disclosed |
| WO-2000037457-A1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY | SCHERING CORPORATION (US) | 2000-06-29 | — | — | WO | disclosed |