Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 12/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940399 | 0.84 | PTAFR (0.39) | PTAFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6943758 | 0.84 | PTAFR (0.60) | PTAFR | |
| SCHEMBL7695791 | 0.83 | PTAFR (0.77) | PTAFR | |
| SCHEMBL7594055 | 0.83 | PTAFR (0.77) | PTAFR | |
| SCHEMBL7133900 | 0.83 | PTAFR (0.77) | PTAFR | |
| SCHEMBL7133697 | 0.81 | PTAFR (0.56) | PTAFR | |
| SCHEMBL6944370 | 0.81 | PTAFR (0.37) | PTAFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9660558 | 0.79 | PTAFR (0.74) | PTAFR | |
| SCHEMBL10429013 | 0.78 | PTAFR (0.69) | PTAFR | |
| SCHEMBL9691535 | 0.77 | PTAFR (0.81) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121338-A4 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | MILLENNIUM PHARM INC (US) | 2003-03-12 | — | — | EP | disclosed |
| US-20020128491-A1 | Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans | RAO ALLA VENKATA RAMA (IN) | 2002-09-12 | — | — | US | disclosed |
| US-6403814-B1 | REACTING WITH GRIGNARD REAGENT COMPOUND HAVING CARBON SUBSTITUTED BY ACETYLENE GROUP, ARYL GROUP AND HYDROXYL GROUP, HYDROGENATING ACETYLENE MOIETY OF REACTION PRODUCT, CYCLIZING TO PROVIDE DI-ARYL TETRAHYDROFURAN | MILLENNIUM PHARMACEUTICALS, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1121338-A1 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | Millennium Pharmaceuticals, Inc. (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023409-A1 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | LEUKOSITE, INC. (US) | 2000-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128491-A1 | Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans | TPMT, TPI1, GTF2I | PTAFR 2062/4885PDE4A 1623/4885PDE4B 1681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.