Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947352 | 0.89 | ADAM17 (0.51) | ADAM17CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6943306 | 0.86 | ADAM17 (0.45) | ADAM17MMP2MMP3MMP7TGFBR1 | |
| SCHEMBL6946107 | 0.85 | ADAM17 (0.38) | ADAM17MMP2MMP3MMP7P2RX3 | |
| SCHEMBL6945960 | 0.85 | ADAM17 (0.51) | ADAM17MMP2TGFBR1CA1CA2 | |
| SCHEMBL6942385 | 0.85 | ADAM17 (0.45) | ADAM17TGFBR1P2RX3POLB | |
| SCHEMBL6942441 | 0.84 | ADAM17 (0.45) | ADAM17TGFBR1P2RX3 | |
| SCHEMBL6940024 | 0.84 | ADAM17 (0.48) | ADAM17MMP2MMP3POLB | |
| SCHEMBL6946888 | 0.83 | ADAM17 (0.48) | ADAM17CCNA2CDK2CCNA1CDK5 | |
| SCHEMBL6944673 | 0.83 | ADAM17 (0.46) | ADAM17P2RX3 | |
| SCHEMBL6943881 | 0.83 | ADAM17 (0.57) | ADAM17MMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |