Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694597 | 0.86 | PTGS2 (0.37) | ADORA2AADORA1ADORA3PTGS2MAPT | |
| SCHEMBL1095114 | 0.85 | ADORA3 (0.42) | ADORA2AADORA1ADORA3LMNA | |
| SCHEMBL3482976 | 0.78 | ADORA3 (0.32) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL3482975 | 0.78 | MEN1 (0.34) | — | |
| SCHEMBL15516643 | 0.77 | ALDH1A1 (0.38) | MAPTRAB9ALMNA | |
| SCHEMBL6752490 | 0.75 | CNR2 (0.34) | — | |
| SCHEMBL188339 | 0.74 | NOTUM (0.33) | HTTRECQL | |
| SCHEMBL1129002 | 0.73 | HDAC8 (0.48) | ADORA2AADORA1ADORA3POLBADORA2B | |
| SCHEMBL8558135 | 0.73 | ADORA2A (0.48) | ADORA2AADORA1ADORA3ADORA2BMAPT | |
| SCHEMBL12419295 | 0.73 | ADORA2A (0.40) | ADORA2AADORA1ADORA3POLBADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |