Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 3/20 | 0.31 |
| ▸ | MMP2 | P08253 | 3/20 | 0.31 |
| ▸ | MMP3 | P08254 | 3/20 | 0.31 |
| ▸ | MMP8 | P22894 | 3/20 | 0.31 |
| ▸ | MMP13 | P45452 | 3/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942478 | 0.99 | ADAM17 (0.41) | ADAM17P2RX3TGFBR1METAP2METAP1 | |
| SCHEMBL6947352 | 0.91 | ADAM17 (0.51) | ADAM17P2RX3TGFBR1ALDH1A1GAA | |
| SCHEMBL6939783 | 0.89 | ADAM17 (0.37) | ADAM17P2RX3TGFBR1ALDH1A1POLB | |
| SCHEMBL6945960 | 0.87 | ADAM17 (0.51) | ADAM17P2RX3TGFBR1MMP2CA1 | |
| SCHEMBL6940024 | 0.86 | ADAM17 (0.48) | ADAM17CTSDALDH1A1POLBMMP1 | |
| SCHEMBL6943306 | 0.85 | ADAM17 (0.45) | ADAM17P2RX3TGFBR1GAAPOLB | |
| SCHEMBL6942385 | 0.85 | ADAM17 (0.45) | ADAM17P2RX3TGFBR1ALDH1A1POLB | |
| SCHEMBL6943824 | 0.84 | ADAM17 (0.55) | ADAM17ALDH1A1GAAPOLBMMP1 | |
| SCHEMBL6939403 | 0.84 | ADAM17 (0.55) | ADAM17ALDH1A1GAAPOLBMMP1 | |
| SCHEMBL6944673 | 0.84 | ADAM17 (0.46) | ADAM17P2RX3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |