Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946411 | 0.99 | CYP1A2 (0.41) | CYP1A2CYP2C9CYP2C19HTTPKM | |
| Hydrochloric Acid SCHEMBL6943297 | 0.92 | CYP1A2 (0.40) | CYP1A2CYP2C9CYP2C19HTTPKM | |
| SCHEMBL6946519 | 0.91 | CYP1A2 (0.41) | CYP1A2CYP2C9CYP2C19HTTPKM | |
| Hydrochloric Acid SCHEMBL6940001 | 0.89 | LMNA (0.36) | CYP2C9ALDH1A1LMNASMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL7632203 | 0.88 | CYP1A2 (0.39) | CYP1A2CYP2C9CYP2C19HTTPKM | |
| SCHEMBL6943539 | 0.88 | LMNA (0.37) | CYP2C9ALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7805138 | 0.87 | CYP1A2 (0.40) | CYP1A2CYP2C9CYP2C19HTTPKM | |
| Hydrochloric Acid SCHEMBL6940908 | 0.84 | LMNA (0.39) | CYP1A2CYP2C9CYP2C19ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL6941307 | 0.83 | LMNA (0.38) | HTTALDH1A1LMNASMN1; SMN2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6945703 | 0.83 | MAPT (0.45) | ALDH1A1LMNASMN1; SMN2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |