Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GPX4 | P36969 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939468 | 0.99 | LMNA (0.39) | LMNASMN1; SMN2ALDH1A1CYP3A4THRB | |
| Hydrochloric Acid SCHEMBL6575297 | 0.88 | KMT2A (0.36) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL6940908 | 0.88 | LMNA (0.39) | LMNASMN1; SMN2ALDH1A1CYP3A4THRB | |
| SCHEMBL6574119 | 0.87 | MEN1 (0.36) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL6939901 | 0.87 | LMNA (0.39) | LMNASMN1; SMN2ALDH1A1CYP3A4THRB | |
| Hydrochloric Acid SCHEMBL6941393 | 0.84 | LMNA (0.39) | LMNASMN1; SMN2THRBHPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6944288 | 0.83 | CYP1A2 (0.40) | LMNASMN1; SMN2ALDH1A1CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL6943297 | 0.83 | CYP1A2 (0.40) | LMNASMN1; SMN2ALDH1A1CYP3A4HTT | |
| SCHEMBL6937083 | 0.83 | LMNA (0.40) | LMNASMN1; SMN2THRBHPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6945659 | 0.82 | MTNR1B (0.41) | LMNASMN1; SMN2THRBHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |