Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.47 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944654 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL600479 | 0.81 | ALDH1A1 (0.68) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL9330897 | 0.81 | ALDH1A1 (0.68) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL600478 | 0.81 | ALDH1A1 (0.68) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL20697998 | 0.80 | MAPT (0.47) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL6948401 | 0.80 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL6947763 | 0.80 | MAPT (0.62) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL22701981 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL6948405 | 0.80 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNANPSR1PLIN1 | |
| SCHEMBL6947760 | 0.80 | MAPT (0.62) | ALDH1A1MAPTLMNANPSR1PLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642246-B1 | Potent ligands for nicotinic acetylcholine receptors (nAChRs). Alzheimer's disease, cognitive or attention disorders, anxiety, depression, smoking cessation, neuroprotection, schizophrenia, analgesia, Tourette's syndrome, and Parkinson's | ASTRAZENECA AB (SE) | 2003-11-04 | — | — | US | disclosed |
| EP-1235826-B1 | QUINUCLIDINE ACRYLAMIDES | ASTRAZENECA AB (SE) | 2003-09-03 | — | — | EP | disclosed |
| EP-1235826-A1 | QUINUCLIDINE ACRYLAMIDES | AstraZeneca AB (SE) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001029034-A1 | QUINUCLIDINE ACRYLAMIDES | ASTRAZENECA AB (SE) | 2001-04-26 | — | — | WO | disclosed |