Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.68 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.68 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.68 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600478 | 1.00 | ALDH1A1 (0.68) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| SCHEMBL600479 | 1.00 | ALDH1A1 (0.68) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| Water SCHEMBL9776234 | 0.98 | ALDH1A1 (0.66) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| Water SCHEMBL9776229 | 0.98 | ALDH1A1 (0.66) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| Acetic Acid SCHEMBL28747365 | 0.94 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| SCHEMBL7516062 | 0.83 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| SCHEMBL7516071 | 0.83 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| SCHEMBL4645504 | 0.83 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| SCHEMBL13080235 | 0.83 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTNPSR1PLIN1 | |
| SCHEMBL9847361 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTNPSR1PLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9265768-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-02-23 | — | — | US | disclosed |
| EP-2760838-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2014-08-06 | — | — | EP | disclosed |
| US-20140142074-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-05-22 | — | — | US | disclosed |
| US-20140142074-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-05-22 | — | — | US | disclosed |
| WO-2013045280-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045280-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-04 | — | — | WO | disclosed |
| US-20130079313-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-03-28 | — | — | US | disclosed |
| US-20130079313-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-03-28 | — | — | US | disclosed |
| US-20130079313-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-03-28 | — | — | US | disclosed |
| US-20080261923-A1 | Alkene Mimics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-10-23 | — | — | US | disclosed |
| US-20080261923-A1 | Alkene Mimics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-10-23 | — | — | US | disclosed |
| US-20070027067-A1 | Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-01 | — | — | US | disclosed |
| US-20070027067-A1 | Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-01 | — | — | US | disclosed |
| EP-0408107-B1 | Novel acrylic acid salts, a process for their preparation, pharmaceutical compositions containing them and their use in the medicine | RICHTER GEDEON VEGYESZET (HU) | 1994-04-13 | — | — | EP | disclosed |
| EP-0408106-B1 | Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine | RICHTER GEDEON VEGYESZET (HU) | 1994-04-06 | — | — | EP | disclosed |
| US-5214045-A | Acrylamides having amide substituted by residues of glycine, alanine, aspartic acid, methionine, proline or thiazolidinecarboxylic acid and acrylic group substituted by phenylthio-, phenylsulfinyl- or phenylsulfonyl-groups | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1993-05-25 | — | — | US | disclosed |
| US-5021597-A | Cytoprotective agents, antiulcer, antisecretory agents | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1991-06-04 | — | — | US | disclosed |
| EP-0408107-A2 | Novel acrylic acid salts, a process for their preparation, pharmaceutical compositions containing them and their use in the medicine | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-01-16 | — | — | EP | disclosed |
| EP-0408108-A2 | Pharmaceutical compositions containing acrylic acid derivatives and their use in the medicine | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-01-16 | — | — | EP | disclosed |
| EP-0408106-A2 | Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027067-A1 | Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof | PIN1, PREP, PIN4 | ALDH1A1 4636/4885LMNA 2765/4885MAPT 74/4885 |
| US-20130079313-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | ALDH1A1 59/4885LMNA 1562/4885MAPT 3250/4885 |
| US-20080261923-A1 | Alkene Mimics | PHOSPHO1, PARN, CHAMP1 | ALDH1A1 4597/4885LMNA 1092/4885MAPT 2587/4885 |
| US-20140142074-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | ALDH1A1 59/4885LMNA 1562/4885MAPT 3250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.